Sebastian Triesch
Computational biology · Gene regulation · Plant genomics

Sebastian Triesch

I work where plant genomics and machine learning meet experimental discovery.

  • Institute of Synthetic Biology
  • Heinrich Heine University Düsseldorf
  • CEPLAS
  • Germany

About

I am a computational biologist and quantitative geneticist interested in how genomes encode biological function. My work combines plant genomics, biostatistics, regulatory sequence analysis and machine learning to connect genetic variation with gene regulation and complex traits.

I am a biochemist by training and began my scientific career in experimental biology. During my PhD, I moved from the bench into computational genomics, generating and analyzing multi-omics, epigenomic and single-cell datasets for non-model plant systems.

In my current postdoctoral work, I use machine learning as one quantitative tool to model regulatory DNA, interpret genetic variation and understand how plant genomes shape complex traits.

Software

PETAL

Gene regulation Deep learning Python Web app

PETAL is an end-to-end machine learning platform for predictive modeling of regulatory DNA sequences. It combines model prediction, interpretation and sequence evolution workflows in a web-accessible format.

PETAL is currently being deployed and will be released soon.

SEPAL

Embedded system Plant environment control Raspberry Pi

SEPAL is a low-cost, modular plant environment monitoring system built on a Raspberry Pi. It provides a user-friendly interface for monitoring environmental parameters such as temperature, humidity and light in plant growth chambers or greenhouses.

Helixer

Genome annotation Deep learning Python

Helixer is a deep learning-based gene annotation tool for eukaryotic genomes. It combines deep neural networks with a hidden Markov model to predict primary gene models from genomic DNA sequences.

I contributed to Helixer as a co-author involved in the biological validation and interpretation of the model.

Predmoter

Epigenetics Deep learning Python

Predmoter is a deep learning-based tool for predicting plant promoter and enhancer regions across species.

I contributed to Predmoter as a co-author involved in project conceptualization, data analysis and interpretation of the model.

Publications

  1. Triesch, S., Reichel-Deland, V., Valderrama Martín, J.M., Melzer, M., Schlüter, U., Weber, A.P.M. Single-nuclei sequencing of Moricandia arvensis reveals bundle-sheath cell function in the photorespiratory shuttle of C3–C4 intermediate Brassicaceae. Journal of Experimental Botany, eraf245 (2025).
  2. Dickinson, P.J., Triesch, S., Schlüter, U., Weber, A.P.M., Hibberd, J.M. A transcription factor module mediating C2 photosynthesis in the Brassicaceae. EMBO Reports, 1–8 (2025).
  3. Holst, F., Bolger, A., Günther, C., Maß, J., Triesch, S., Kindel, F., Kiel, N., Saadat, N., Ebenhöh, O., Usadel, B., Schwacke, R., Bolger, M., Weber, A.P.M., Denton, A.K. Helixer: ab initio prediction of primary eukaryotic gene models combining deep learning and a hidden Markov model. Nature Methods, 1–8 (2025).
  4. Triesch, S., Denton, A.K., Bouvier, J.W., Buchmann, J.P., Reichel-Deland, V., Guerreiro, R.N.F.M., Busch, N., Schlüter, U., Stich, B., Kelly, S., Weber, A.P.M. Transposable elements contribute to the establishment of the glycine shuttle in Brassicaceae species. Plant Biology 26(2): 270–281 (2024).
  5. Kindel, F., Triesch, S., Schlüter, U., Randarevitch, L.A., Reichel-Deland, V., Weber, A.P.M., Denton, A.K. Predmoter: cross-species prediction of plant promoter and enhancer regions. Bioinformatics Advances 4(1): vbae074 (2024).
  6. Germann, A.T., Nakielski, A., Dietsch, M., Petzel, T., Moser, D., Triesch, S., Westhoff, P., Axmann, I.M. A systematic overexpression approach reveals native targets to increase squalene production in Synechocystis sp. PCC 6803. Frontiers in Plant Science 14: 1024981 (2023).
  7. Segura Broncano, L., Pukacz, K.R., Reichel-Deland, V., Schlüter, U., Triesch, S., Weber, A.P.M. Photorespiration is the solution, not the problem. Journal of Plant Physiology 282: 153928 (2023).
  8. Guerreiro, R., Bonthala, V.S., Schlüter, U., Hoang, N.V., Triesch, S., Schranz, M.E., Weber, A.P.M., Stich, B. A genomic panel for studying C3–C4 intermediate photosynthesis in the Brassiceae tribe. Plant, Cell & Environment 46(11): 3611–3627 (2023).